Broader impact

Consequences of testing beyond clinical effectiveness and cost-effectiveness (e.g. acceptability, social, psychological, legal, ethical, societal, organizational consequences and other aspects). 


  • Psychological impact of genetic testing for familial hypercholesterolemia: An RCT in a population previously aware of their hypercholesterolemia found that finding a mutation by genetic testing did not reduce patients' perceptions of control over the disease and adherence to risk-reducing behaviors, but did affect their perceptions of how control is most effectively achieved. 

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