Topic outline

  • Reliable estimates of biological variation - the way forward

    Aasne Karine AarsandSpeaker: Aasne Karine Aarsand (NO)

    Moderator: Bill Bartlett (UK)

    Date: 6th March 2018 at 18:00 CET

    Abstract
    Biological variation (BV) data has many appliances in the daily laboratory life, being used both when evaluating the diagnosis and monitoring of disease and for setting analytical performance specifications. Thus, the quality of our work directly depends on the reliability of the BV estimates used as basis for these processes. Widely varying BV estimates are available for different measurands, and it is likely that this may be caused by differences in study design and statistical handling. Addressing this issue, the EFLM established in 2014 an EFLM Task and Finish Group (TFG) for the Biological Variation Database. The TFG is made up by members from the EFLM Working Group on Biological Variation, the Analytical Quality Commission of the Spanish Society of Clinical Chemistry and experts in the area. The TFG has developed a critical appraisal list for evaluation of studies on BV and this will be used as basis for the setup of a database with measures of BV, the derived performance specifications and the evidence behind it.

    About the speaker
    Aasne K. Aarsand, M.D. Ph.D., is a consultant in medical biochemistry at the Norwegian Porphyria Centre (NAPOS) and the Laboratory of Clinical Biochemistry, Haukeland University Hospital and at the Norwegian Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway. She received her Ph.D. in porphyria diagnostics from the University of Bergen in 2012. Her research interests include the evidence-based use of diagnostic markers, in particular in the porphyrias, biological variation and harmonisation of the total testing process. She is Chair of the Biological Variation Working Group and a member of the Task and Finish Group for the Biological Variation Database in the European Federation of Clinical Chemistry and Laboratory Medicine. She is also manager of the European Porphyria Registry and part of the Steering Committee of the European Porphyria Network (EPNET).
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